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Molecular Biology and Evolution|August 14, 2019

Sequenceserver: a modern graphical user interface for custom BLAST databases

Authors: Anurag Priyam1, Ben J Woodcroft2, Vivek Rai3, Ismail Moghul1, Alekhya Munagala3, Filip Ter1, Hiten Chowdhary3, Iwo Pieniak1, Lawrence J Maynard1, Mark Anthony Gibbins4, HongKee Moon5, Austin Davis-Richardson6, Mahmut Uludag7,8, Nathan S Watson-Haigh9, Richard Challis10, Hiroyuki Nakamura11, Emeline Favreau1, Esteban A Gómez1, Tomás Pluskal12, Guy Leonard13, Wolfgang Rumpf14,15, Yannick Wurm1

DOI: 10.1093/molbev/msz185

  • 1. School of Biological and Chemical Sciences, Queen Mary University
  • 2. School of Chemistry and Molecular Biosciences, University
  • 3. Department of Biotechnology, Indian Institute of Technology Kharagpur
  • 4. Department of Computer Science, Royal Holloway University
  • 5. Scientific Computing Facility, Max Planck Institute of Molecular Cell Biology and Genetics
  • 6. San Francisco, CA
  • 7. Computational Bioscience Research Center
  • 8. King Abdullah University of Science and Technology
  • 9. Bioinformatics Hub, School of Biological Sciences, University
  • 10. Institute of Evolutionary Biology, University
  • 11. Spiber Inc.
  • 12. Whitehead Institute for Biomedical Research
  • 13. Living Systems Institute, University of Exeter, Exeter, United Kingdom
  • 14. The Institute for Genomic Medicine
  • 15. The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus,

From “Sequenceserver: A Modern Graphical User Interface for Custom BLAST Databases” by Anurag Priyam et al.. Licensed under CC-BY 4.0


Abstract

Comparing newly obtained and previously known nucleotide and amino-acid sequences underpins modern biological research. BLAST is a well-established tool for such comparisons but is challenging to use on new data sets. We combined a user-centric design philosophy with sustainable software development approaches to create Sequenceserver, a tool for running BLAST and visually inspecting BLAST results for biological interpretation. Sequenceserver uses simple algorithms to prevent potential analysis errors and provides flexible text-based and visual outputs to support researcher productivity. Our software can be rapidly installed for use by individuals or on shared servers.

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